Volume 1, Issue 2 (11-2019)                   jsrc 2019, 1(2): 36-44 | Back to browse issues page

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Askarian S. the application of non-viral nanocarriers for gene delivery . jsrc. 2019; 1 (2) :36-44
URL: http://jsrc.thums.ac.ir/article-1-41-en.html
Abstract:   (1193 Views)
Background: one of the most important challenges in gene therapy is the lack of efficient gene delivery systems. Nanocarriers are placed in two viral and non-viral categories. Despite the high transfer efficiency and fast gene delivery offered by viral carriers, their application has been decreased due to low transfer capacity, possibility of activating proto-oncogenes and induction of potent immune responses. In contrast and despite lower efficiency, non-viral nanocarriers have had a growing usage in gene delivery studies due to advantages such as the capability of transferring big gene pieces, lower infection risk, low immunogenicity, structural flexibility and ease of design.
Objective: this study assessed the studies published by Iranian researchers which deal with gene delivery using non-viral nanocarriers.
Research method: the necessary data for this review were obtained solely from the research articles published by May 2018 based on databases including, Iran Research Information System, SID, PubMed, Scopus and ScienceDirect.
Findings: Iranian researchers have dealt with production of non-viral nanocarriers and assessment of gene delivery using them in more than 800 research articles. Among them, polyethyleneimine (PEI) -based (25%), dendrimer (20%) and liposomal nanocarriers were the most frequently used in gene delivery studies.
Conclusion: in studies by Iranian researchers, synthesis, of transfection performance improvement and decrease of cellular toxicity of different non-viral nanocarriers has been evaluated and many candidates for the purpose of gene delivery has been proposed. Targeted transfer of nanocarriers using different molecules such as Aptamers is increasing (25 articles) which requires more consideration.
Keywords: Gene delivery, Nanoparticles, Non-viral vector, IRAN.
Full-Text [PDF 27 kb]   (188 Downloads)    
Type of Study: Research | Subject: Special
Received: 2019/09/2 | Accepted: 2019/10/22 | Published: 2019/11/27

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